Coagulation and hemostatic parameters in healthy upper Egyptian women of child bearing age

This study tested the coagulation and hemostatic parameters of 538 normal Egyptian women of child-bearing age using standardized laboratory procedures to facilitate comparison with results reported in other countries. The studied parameters are pro-thrombin time, partial thromboplastin time, fibrinogen concentration, coagulation factors. VII,X, activity, platelet count, mean platelet volume, and platelet aggregation with A.D.P. and antithrombin III activity. It was found that there are important differences in the coagulation and hemostatic profiles of women of childbearing age in our locality compared with that reported abroad

Thrombin-antithrombin activity and C1-inactivator in type I diabetics

Previous studies on Diabetes mellitus Type 1 ended in a controversy as to whether there was an increased or decreased fibrinolysis. Also whether fibrinolysis if present was primary or secondary to a hypercoagulable state. The results of screening tests of fibrinolysis are frequently indecisive. C[1]-Inactivator [C[1]-1] [%] as inhibitor of fibrinolysis and thrombin anti-throbmin [TA T] [ug/ml] complex as a sensitive index of the coagulation cascade were determined in 41 male patients with type I diabetes mellitus without complications and in 25 patients of the same disease with microvascular complications [retinopathy, nephropathy and/or neuropathy]. The effect of duration of the disease and the response of the disease to control, were studied. In spite of the fact that screening results of fibrinolysis were not decisive, C[1] -1 and TA T were specific and indicative. TA T was higher in complicated cases [m 9.7 +/- 2.1 SD] than in non-complicated ones [m 5.6 +/- 2.7 SD]; and in uncontrolled complicated cases [m 11.3 +/- 3.0 SD] than in controlled ones [m 9.7 +/- 2.1 SD]. The effect of control was evident also in non-complicated cases where TAT was higher in uncontrolled [m 6.2 +/- 1.9 SD] versus controlled ones [5.6 +/- 2.7 SD]. The longer the duration of the disease the higher the level of TA T, where it was [m 7.2 +/- 2.1 SD] in 1-2 yrs duration and reached m 10.2 +/- 3.1 SD in 5-9 yrs duration. C[1]-l was also higher in complicated diabetes [m 118.6. +/- 18.5 SD] than in non-complicated cases [m 107.5 +/- 16.0 SD] and in both complicated uncontrolled cases [116.3 +/- 15.0 SD] than in complicated controlled ones [118.6 +/- 18.5 SD] also in non-complicated uncontrolled cases [m 115.0 +/- 18.8 SD] than in controlled ones [m 107.5 +/- 160 SD]. The results point to an increased rate of fibrinolysis in response to increased hypercoagulable state in type I Diabetes Mellitus and this is more accentuated the longer the duration of the diseases and that both improve on a better control of the disease

Family study of thalassaemia in Assiut

Family studies were done for a patient with pallor resistant to iron therapy and 4 patients with evidence of hemolytic disorders. This entailed the inclusion of 16 other subjects in this study. All subjects were of pure Egyptian stock born in the city of Assiut. An adult male and adult female were diagnosed homozygous thalassaemia. Four cases of heterozygous thalassaemia were diagnosed. They comprised a female with pallor resistant to iron - therapy, her father and her brother and the mother of a girl with a hemolytic disorder. In all of them, the thalassaemia gene was associated with gene for Hb Knossos in cis. Five cases with thalassaemia intermedia resulting from different genetic interactions comprised a young girl, an adult female and her brother and 2 adult males. All showed evidence of hemolytic disorder. The girl proved to be a compound heterozygous state for conventional B-thalassaemia gene and Hb Knossos. The adult female, her brother and one of the adult males were probably compound heterozygous states for a conventional B-thalassaemia gene and silent one. The other adult male was probably diagnosed homozygous B-thalassaemia interacting with one -thalassaemia gene